Effects of CETP inhibition on triglyceride-rich lipoprotein composition and apoB-48 metabolism
نویسندگان
چکیده
منابع مشابه
Triglyceride-rich lipoprotein remnant levels and metabolism
mong the major components of the standard plasma lipid rofile, the total triglyceride (TG) level is generally considred the weakest risk factor for atherosclerosis, for which here are several likely contributing reasons. First, TG is eadily metabolized and is not a major constituent of therosclerotic plaque. Second, plasma TG varies greatly rom day to day in the fasting state and even more in t...
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Pro-protein convertase subtilisin-kexin 9 (PCSK9) is known to affect low-density lipoprotein (LDL) metabolism, but there are indications from several lines of research that it may also influence the metabolism of other lipoproteins, especially triglyceride-rich lipoproteins (TRL). This review summarizes the current data on this possible role of PCSK9. A link between PCSK9 and TRL has been sugge...
متن کاملMarkers of triglyceride-rich lipoprotein remnant metabolism in visceral obesity.
BACKGROUND Triglyceride-rich lipoprotein remnants are atherogenic, and this may be particularly important in visceral obesity. We investigated remnant metabolism in obese men by measuring remnant-like particle-cholesterol (RLP-C), apolipoprotein (apo) B-48, apoC-III, and the clearance of a labeled remnant-like emulsion. METHODS Fasting RLP-C, apoB-48, and apoC-III concentrations were measured...
متن کاملMetabolism of apolipoproteins B-48 and B-100 of triglyceride-rich lipoproteins in normal and lipoprotein lipase-deficient humans.
The metabolism of apolipoproteins B-48 and B-100 (apo B-48 and B-100) in large triglyceride-rich lipoproteins (300 to 1500 A in diameter) has been compared in three normal subjects and two subjects with genetically determined deficiency of lipoprotein lipase. The triglyceride-rich lipoproteins were obtained from a lipoprotein lipase-deficient donor 4 hr after a fat-rich meal in order to obtain ...
متن کاملGlucose-stimulated insulin secretion suppresses hepatic triglyceride-rich lipoprotein and apoB production.
The current study assessed in vivo the effect of insulin on triglyceride-rich lipoprotein (TRL) production by rat liver. Hepatic triglyceride and apolipoprotein B (apoB) production were measured in anesthetized, fasted rats injected intravenously with Triton WR-1339 (400 mg/kg). After intravascular catabolism was blocked by detergent treatment, glucose (500 mg/kg) was injected to elicit insulin...
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ژورنال
عنوان ژورنال: Journal of Lipid Research
سال: 2012
ISSN: 0022-2275
DOI: 10.1194/jlr.m019570